Abstract | OBJECTIVES: To determine whether impaired reactivity to dilatory agonists could contribute to pulmonary hypertension, and whether there are gender differences in pulmonary vasodilator reactivity. METHODS: RESULTS: Relaxation to ACh, ADM, and CGRP was endothelium-dependent. Hypertensive pulmonary arterial rings relaxed less to ACh and CGRP than controls in both genders. Female pulmonary hypertensive muscle was more rather than less reactive to ADM compared with controls. ADM-induced relaxation of NE contractions was 2.4 times greater in female compared with male control rings and 5.5 times greater in female compared with male hypertensive preparations. Gender differences in relaxation responses were similar for CGRP. MCT-treated female arterial rings relaxed more than did MCT-treated male arterial muscle in response to ACh. No difference in ACh relaxation was found between genders for controls. CONCLUSIONS:
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Authors | C Subah Packer, Tomalyn C Johnson, Palaniswamy Vijay, Thomas G Sharp, Deepika Jha, Shannon M Tighe, Helen V Chukwu |
Journal | The journal of gender-specific medicine : JGSM : the official journal of the Partnership for Women's Health at Columbia
(J Gend Specif Med)
Vol. 6
Issue 3
Pg. 30-8
( 2003)
ISSN: 1523-7036 [Print] United States |
PMID | 14513574
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Endothelins
- Peptides
- Vasodilator Agents
- Adrenomedullin
- Monocrotaline
- Calcitonin Gene-Related Peptide
- Acetylcholine
- Norepinephrine
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Topics |
- Acetylcholine
(pharmacology)
- Adrenomedullin
- Animals
- Calcitonin Gene-Related Peptide
(pharmacology)
- Endothelins
- Female
- Hypertension, Pulmonary
(chemically induced)
- Male
- Monocrotaline
- Norepinephrine
- Peptides
(pharmacology)
- Pulmonary Artery
(drug effects)
- Rats
- Rats, Sprague-Dawley
- Sex
- Vasodilation
(drug effects)
- Vasodilator Agents
(pharmacology)
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