Miltefosine (Impavido): the first oral treatment against leishmaniasis.

Abstract

Miltefosine is a novel antileishmanial drug that has significant selectivity in both in vitro and in vivo models. Clinical efficacy was demonstrated for the treatment of visceral leishmaniasis with the advantage of oral administration over the currently recommended antileishmanial drugs that require parenteral administration. Miltefosine produces high cure rates also in patients resistant to the standard antimonial therapy.

• Authors: H Sindermann, S L Croft, K R Engel, W Bommer, H J Eibl, C Unger, J Engel
• Journal: Medical microbiology and immunology (Med Microbiol Immunol) Vol. 193 Issue 4 Pg. 173-80 (Nov 2004) ISSN: 0300-8584 [Print] Germany
• PMID: 14513375 (Publication Type: Journal Article)

Chemical References

• Antiprotozoal Agents
• Phosphorylcholine
• miltefosine

Topics

• Administration, Oral
• Animals
• Antiprotozoal Agents (adverse effects, pharmacokinetics, therapeutic use)
• Humans
• Leishmaniasis (drug therapy, parasitology)
• Phosphorylcholine (adverse effects, analogs & derivatives, pharmacokinetics, therapeutic use)