Abstract | BACKGROUND:
Heterotrimeric G proteins play a pivotal role in the intracellular transduction of many transmitter-receptor interactions. Alterations in signal transduction and in G protein concentrations have been reported in seasonal and nonseasonal affective disorder. A single-nucleotide polymorphism (C825T) in the G protein beta3-subunit gene has been shown to influence intracellular response to G protein-coupled stimuli, and the T-allele of this polymorphism has been associated with hypertension and major depression. METHODS: RESULTS: Patients with SAD were significantly more likely to be either homo- or heterozygous for the G(beta)3 T-allele when compared with healthy control subjects (p =.001), and they displayed a higher frequency of the G(beta)3 C825T T-allele (p =.021). The polymorphism was not associated with seasonality, which is the tendency to experience variations in mood and behavior with changing of the seasons. CONCLUSIONS: The G(beta)3 C825T polymorphism was associated with SAD in our study sample. This finding strengthens the evidence for the involvement of G protein-coupled signal transduction in the pathogenesis of affective disorder.
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Authors | Matthäus Willeit, Nicole Praschak-Rieder, Peter Zill, Alexander Neumeister, Manfred Ackenheil, Siegfried Kasper, Brigitta Bondy |
Journal | Biological psychiatry
(Biol Psychiatry)
Vol. 54
Issue 7
Pg. 682-6
(Oct 01 2003)
ISSN: 0006-3223 [Print] United States |
PMID | 14512207
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- G-protein beta3 subunit
- Threonine
- Heterotrimeric GTP-Binding Proteins
- Cysteine
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Topics |
- Adolescent
- Adult
- Aged
- Alleles
- Chi-Square Distribution
- Cysteine
(genetics)
- Female
- Genotype
- Heterotrimeric GTP-Binding Proteins
(genetics)
- Humans
- Male
- Middle Aged
- Polymerase Chain Reaction
(methods)
- Polymorphism, Single Nucleotide
- Seasonal Affective Disorder
(classification, genetics)
- Threonine
(genetics)
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