Abstract | BACKGROUND: MATERIAL AND METHODS: In nine patients, we monitored the RR-interval and systolic blood pressure at supine rest before (baseline 1) and after gastrostomy feeding (GF1). One day later, recordings were repeated after clonidine intake (baseline 2, GF2). We determined spectral powers of RR-interval and systolic blood pressure in the low- (LF) and high-frequency range (HF). Sympathovagal balance was determined from the LF/HF ratio of RR-interval. Baroreflex sensitivity was assessed from the alpha-index of systolic blood pressure and RR-interval. RESULTS:
Gastrostomy feeding decreased RR-interval, while systolic blood pressure remained stable. Clonidine induced higher RR-intervals before and after gastrostomy feeding but decreased systolic blood pressure at baseline only. Gastrostomy feeding decreased HF-power of RR-interval significantly without clonidine, but only slightly after premedication. Clonidine increased the HF-power of RR-interval slightly at baseline and significantly after gastrostomy feeding. Gastrostomy feeding increased the LF/HF ratio without clonidine only. Clonidine decreased the LF/HF ratio at baseline and after gastrostomy feeding. Gastrostomy feeding did not change baroreflex sensitivity, but baroreflex sensitivity was higher at visit 2 than visit 1. CONCLUSIONS: In familial dysautonomia, clonidine augments baroreflex sensitivity and parasympathetic modulation. The resulting cardiovascular stabilization might attenuate feeding-induced crises.
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Authors | H Marthol, M Tutaj, M Brys, C M Brown, M J Hecht, D Berlin, F B Axelrod, M J Hilz |
Journal | European journal of clinical investigation
(Eur J Clin Invest)
Vol. 33
Issue 10
Pg. 912-8
(Oct 2003)
ISSN: 0014-2972 [Print] England |
PMID | 14511364
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Adrenergic alpha-Agonists
- Clonidine
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Topics |
- Adolescent
- Adrenergic alpha-Agonists
(therapeutic use)
- Baroreflex
(drug effects)
- Blood Pressure
(drug effects)
- Child
- Clonidine
(therapeutic use)
- Dysautonomia, Familial
(drug therapy, physiopathology)
- Enteral Nutrition
(adverse effects)
- Female
- Gastrostomy
- Heart Rate
(drug effects)
- Humans
- Male
- Postprandial Period
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