HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Phenotypic alteration in malignant transformation of colonic villous tumours: with special reference to a comparison with tubular tumours.

AbstractAIMS:
To clarify the cellular differentiation of colorectal villous tumours in malignant transformation, compared with that of tubular tumours (tubular adenoma and adenocarcinoma arising in tubular adenoma).
METHODS AND RESULTS:
Forty-nine cases of colorectal villous tumours [six cases of low-grade villous adenoma, 21 of high-grade villous adenoma (VA), nine of invasive carcinoma in villous adenoma (CIVA), and 13 of pure villous carcinoma (PVC)] and 46 cases of tubular tumours [14 cases of low-grade and 17 of high-grade tubular adenoma (TA), and 15 cases of carcinoma in tubular adenoma (CITA)] were selected for this study based on their expression patterns of CD10 (small intestinal brush border), MUC2 (intestinal goblet cell), and HGM (gastric foveolar epithelium). HGM was more frequently expressed in the adenomatous components of villous tumours (63%) than in those of tubular tumours (14%) (P < 0.05). CD10 expression of high-grade TAs (47%) and carcinomas arising in TA (60%) was significantly higher than that of villous tumours (0%) (P < 0.05).
CONCLUSIONS:
There were significant differences in the phenotypic expression of adenoma and adenocarcinoma between villous and tubular tumours, respectively. Villous tumours have a pathway of malignant transformation different from that of tubular tumours. Because of biological differences, colorectal villous tumours should be distinguished from tubular neoplasia. The analysis of the phenotype of colorectal neoplasms is useful for the evaluation of tumour progression.
AuthorsM Takata, T Yao, K-I Nishiyama, H Nawata, M Tsuneyoshi
JournalHistopathology (Histopathology) Vol. 43 Issue 4 Pg. 332-9 (Oct 2003) ISSN: 0309-0167 [Print] England
PMID14511251 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Biomarkers, Tumor
  • MUC2 protein, human
  • Mucin-2
  • Mucins
  • Neprilysin
Topics
  • Adenocarcinoma (chemistry, pathology, surgery)
  • Adenoma, Villous (chemistry, pathology, surgery)
  • Adult
  • Aged
  • Aged, 80 and over
  • Biomarkers, Tumor (analysis)
  • Cell Transformation, Neoplastic (pathology)
  • Colonic Neoplasms (chemistry, pathology, surgery)
  • Female
  • Humans
  • Immunoenzyme Techniques
  • Male
  • Middle Aged
  • Mucin-2
  • Mucins (analysis)
  • Neoplasms, Multiple Primary
  • Neprilysin (analysis)
  • Phenotype

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: