Synthesis of oligosaccharides on soluble high-molecular-weight branched polymers in combination with purification by nanofiltration.

Abstract

[structure: see text] An efficient approach for polymer-supported oligosaccharide synthesis is described whereby branched and high-molecular-weight PEG derivatives are used in combination with purification by nanofiltration. This methodology was applied to the preparation of a tetraglucoside and the tumor-associated antigen Le(x).

• Authors: Debatosh Majumdar, Tong Zhu, Geert-Jan Boons
• Journal: Organic letters (Org Lett) Vol. 5 Issue 20 Pg. 3591-4 (Oct 02 2003) ISSN: 1523-7060 [Print] United States
• PMID: 14507180 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antigens, Tumor-Associated, Carbohydrate
• Lewis Blood Group Antigens
• Oligosaccharides
• Polyethylene Glycols

Topics

• Antigens, Tumor-Associated, Carbohydrate (chemistry, isolation & purification)
• Filtration (methods)
• Lewis Blood Group Antigens (chemistry)
• Molecular Weight
• Nanotechnology (methods)
• Oligosaccharides (chemical synthesis, chemistry, isolation & purification)
• Polyethylene Glycols (chemistry)
• Solubility