Abstract | BACKGROUND: METHODS: RESULTS: Adding ethanol to a low-fat diet had no effect on lesion size. Similarly, ethanol had no effect on lesion size in LDLR-/- mice consuming a high saturated fat diet. Adding ethanol to a high-fat, cholate-containing diet for either strain resulted in a 25% to 50% reduction in lesion size. Dietary cholate increased and ethanol reduced NF-kappaB binding activity in the aorta. CONCLUSIONS: These results suggest that ethanol inhibits atherosclerosis in the presence of dietary cholate, which may occur via an anti-inflammatory mechanism.
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Authors | Mark A Deeg |
Journal | Alcoholism, clinical and experimental research
(Alcohol Clin Exp Res)
Vol. 27
Issue 9
Pg. 1499-506
(Sep 2003)
ISSN: 0145-6008 [Print] England |
PMID | 14506412
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Cholates
- Cholesterol, HDL
- Dietary Fats
- NF-kappa B
- Triglycerides
- Ethanol
- Cholesterol
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Topics |
- Alcohol Drinking
(pathology)
- Animals
- Aorta, Thoracic
(pathology)
- Arteriosclerosis
(blood, pathology, prevention & control)
- Cholates
(pharmacology)
- Cholesterol
(blood)
- Cholesterol, HDL
(blood)
- Coronary Artery Disease
(blood, pathology, prevention & control)
- Coronary Vessels
(pathology)
- Diet, Atherogenic
- Diet, Fat-Restricted
- Dietary Fats
(administration & dosage, adverse effects)
- Disease Models, Animal
- Ethanol
(pharmacology)
- Male
- Mice
- Mice, Inbred C57BL
- Muscle, Smooth, Vascular
(pathology)
- NF-kappa B
(metabolism)
- Triglycerides
(blood)
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