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Effects of wogonin, a plant flavone from Scutellaria radix, on skin inflammation: in vivo regulation of inflammation-associated gene expression.

Abstract
Flavonoids from plant origin show anti-inflammatory activity in vitro and in vivo. In addition to inhibition of inflammation-associated enzymes, such as cyclooxygenases (COX) and lipoxygenases, they have been found to regulate the expression of inflammation-associated proteins from in vitro experiments. In order to prove in vivo behavior and the potential for beneficial use against inflammatory skin disorders, the effect of wogonin (5,7-dihydroxy-8-methoxyflavone) on in vivo expression of several inflammation-associated genes was examined in the intact as well as in the inflamed mouse skin by reverse transcriptase-polymerase chain reaction analysis. When applied topically on the intact skin, only a high dose treatment of wogonin (1000 microg/ear/3 days) slightly increased COX-1 and fibronectin mRNA. On the other hand, wogonin at the doses of 250-1000 microg/ear/3 days potently lowered mRNA levels of COX-2 and tumor necrosis factor-alpha with less effect on intercellular adhesion molecule-1 and interleukin-1beta in a sub-chronic skin inflammation model of tetradecanoylphorbol-13-acetate-induced ear edema (multiple treatment). The decrease of prostaglandin E(2) concentration (27.3-34.3%) was concomitantly observed in the wogonin-treated groups. A similar effect was also observed in an acute inflammation model of arachidonic acid-induced ear edema. From the present study, wogonin was proved to differentially regulate the expression of inflammation-associated genes in vivo and to become a useful therapeutic agent for skin inflammatory diseases mainly due to its modulation of the expression of proinflammatory molecules.
AuthorsYeon Sook Chi, Hyun Lim, Haeil Park, Hyun Pyo Kim
JournalBiochemical pharmacology (Biochem Pharmacol) Vol. 66 Issue 7 Pg. 1271-8 (Oct 01 2003) ISSN: 0006-2952 [Print] England
PMID14505806 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Drugs, Chinese Herbal
  • Flavanones
  • Flavonoids
  • Plant Extracts
  • Arachidonic Acid
  • Tetradecanoylphorbol Acetate
  • wogonin
Topics
  • Animals
  • Arachidonic Acid
  • Dermatitis (metabolism)
  • Drugs, Chinese Herbal (chemistry)
  • Flavanones
  • Flavonoids (pharmacology)
  • Gene Expression (drug effects)
  • Inflammation (chemically induced, metabolism)
  • Male
  • Mice
  • Mice, Inbred ICR
  • Plant Extracts (pharmacology)
  • Scutellaria baicalensis (chemistry)
  • Tetradecanoylphorbol Acetate

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