Lupane triterpenes and derivatives with antiviral activity.

Abstract

Betulin and betulinic acid have been modified at the C-3 and C-28 positions and the antiviral activity of derivatives has been evaluated in vitro. It was found that simple modifications of the parent structure of lupane triterpenes produced highly effective agents against influenza A and herpes simplex type 1 viruses.

• Authors: L A Baltina, O B Flekhter, L R Nigmatullina, E I Boreko, N I Pavlova, S N Nikolaeva, O V Savinova, G A Tolstikov
• Journal: Bioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 13 Issue 20 Pg. 3549-52 (Oct 20 2003) ISSN: 0960-894X [Print] England
• PMID: 14505668 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antiviral Agents
• Triterpenes

Topics

• Antiviral Agents (chemistry, pharmacology)
• Microbial Sensitivity Tests
• Triterpenes (chemistry, pharmacology)