Design and synthesis of novel chrysene-linked pyrrolo[2,1-c][1,4]-benzodiazepine hybrids as potential DNA-binding agents.

Abstract

Chrysene-linked pyrrolobenzodiazepine hybrids have been prepared that possess cytotoxicity in some cancer cell lines. They also exhibit promising DNA-binding affinity and this is supported by molecular modeling studies.

• Authors: Ahmed Kamal, G Ramesh, P Ramulu, O Srinivas, Tasneem Rehana, G Sheelu
• Journal: Bioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 13 Issue 20 Pg. 3451-4 (Oct 20 2003) ISSN: 0960-894X [Print] England
• PMID: 14505647 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Chrysenes
• Pyrroles
• pyrrolo(2,1-c)(1,4)benzodiazepine
• chrysene
• Benzodiazepines
• DNA

Topics

• Benzodiazepines (chemical synthesis, chemistry, pharmacology)
• Chrysenes (chemistry)
• DNA (drug effects)
• Pyrroles (chemical synthesis, chemistry, pharmacology)
• Tumor Cells, Cultured