Genotypic association of exonic LGI4 polymorphisms and childhood absence epilepsy.

Abstract

The LGI4 gene is located in a region linked to benign familial infantile convulsions (BFIC) and idiopathic generalized epilepsy. Screening of the LGI4 coding region in BFIC and childhood absence epilepsy (CAE) revealed several frequent exonic polymorphisms. A genotypic association was found for the c.1914GC --> AT polymorphism in 42 CAE patients compared with 110 population controls (chi2 = 6.66, df = 1, P = 0.01), providing evidence for a so far undetected susceptibility allele for CAE in the LGI4 region.

• Authors: Wenli Gu, Thomas Sander, Tim Becker, Ortrud K Steinlein
• Journal: Neurogenetics (Neurogenetics) Vol. 5 Issue 1 Pg. 41-4 (Feb 2004) ISSN: 1364-6745 [Print] United States
• PMID: 14505228 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• LGI3 protein, human
• Nerve Tissue Proteins
• Proteins

Topics

• DNA Mutational Analysis
• Epilepsy, Absence (genetics)
• Exons (genetics)
• Gene Frequency
• Genetic Variation
• Genotype
• Humans
• Infant
• Multigene Family (genetics)
• Nerve Tissue Proteins
• Polymorphism, Genetic
• Proteins (genetics)