Abstract | OBJECTIVE AND DESIGN: MATERIALS AND METHODS: Liver injury was induced in mice by Con A. The in vitro assays for examining the adhesions of spleen T lymphocytes and Jurkat cells to extracellular matrix (ECM) were also performed. RESULTS: CONCLUSION:
N-desulfated heparin may improve immunological liver injury partly via reducing the functions, such as the adhesion to ECM, of T lymphocytes.
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Authors | L Yuan, J G Geng, Q Xu |
Journal | Inflammation research : official journal of the European Histamine Research Society ... [et al.]
(Inflamm Res)
Vol. 52
Issue 9
Pg. 383-9
(Sep 2003)
ISSN: 1023-3830 [Print] Switzerland |
PMID | 14504666
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Fibronectins
- Laminin
- heparin, N-desulfated
- Concanavalin A
- Heparin
- Collagen
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Topics |
- Animals
- Cell Adhesion
(drug effects)
- Cell Division
(drug effects)
- Collagen
(metabolism)
- Concanavalin A
(pharmacology)
- Female
- Fibronectins
(metabolism)
- Heparin
(analogs & derivatives, pharmacology)
- Humans
- Jurkat Cells
- Kinetics
- Laminin
(metabolism)
- Liver
(drug effects, pathology)
- Male
- Mice
- Spleen
(cytology)
- T-Lymphocytes
(cytology, drug effects)
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