Anti-neoplastic effect of halocynthiaxanthin, a metabolite of fucoxanthin.

Abstract

We have reported that fucoxanthin, a natural carotenoid, inhibited the growth of human neuroblastoma GOTO cells. In the present study, we show that a metabolite of fucoxanthin, halocynthiaxanthin, which is isolated from sea squirt Halocynthia roretzi, has a more potent inhibitory effect. Halocynthiaxanthin (5 micrograms/ml) caused complete suppression of GOTO cell proliferation, whereas fucoxanthin reduced the growth rate by only 88.8% compared with the control, at day 2 after the drug treatment. Furthermore, halocynthiaxanthin also inhibited the growth of other human malignant tumor cells. Thus halocynthiaxanthin seems to be a promising anti-neoplastic agent.

• Authors: H Nishino, M Tsushima, T Matsuno, Y Tanaka, J Okuzumi, M Murakoshi, Y Satomi, J Takayasu, H Tokuda, A Nishino
• Journal: Anti-cancer drugs (Anticancer Drugs) Vol. 3 Issue 5 Pg. 493-7 (Oct 1992) ISSN: 0959-4973 [Print] England
• PMID: 1450444 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• DNA, Neoplasm
• Neoplasm Proteins
• RNA, Neoplasm
• Xanthophylls
• fucoxanthin
• Carotenoids
• halocynthiaxanthin

Topics

• Antineoplastic Agents (pharmacology)
• Carotenoids (analogs & derivatives, metabolism, pharmacology)
• Cell Division (drug effects)
• Colonic Neoplasms (drug therapy, pathology)
• DNA, Neoplasm (biosynthesis, drug effects)
• Food
• Gene Expression (drug effects)
• Genes, myc (drug effects, genetics)
• HeLa Cells
• Humans
• Kinetics
• Neoplasm Proteins (biosynthesis, drug effects)
• Neuroblastoma (drug therapy, genetics, pathology)
• Pancreatic Neoplasms (drug therapy, pathology)
• RNA, Neoplasm (biosynthesis, drug effects)
• Stomach Neoplasms (drug therapy, pathology)
• Tumor Cells, Cultured
• Xanthophylls