Abstract | BACKGROUND: The U.S. workplace injury burden is significant. Our objective was to assess the particular impact of aeroallergen, allergic rhinitis, and antihistamine exposures and side effects on the risk of traumatic work-related injuries, and the associated economic impact. METHODS: This is an observational case-control study with 1,223 acute traumatic injury cases that are compared to 1,202 chronic back injury controls. Structured telephone interviews were conducted in 1998 and 1999 on Workers' Compensation applicants injured in 1997. Antihistamine use and pollen levels were measured 2 weeks prior to the injury date. RESULTS: Sedating antihistamine exposures elevated acute injury risk (main effect OR: 2.93). A significant increase in traumatic injury risk was observed for combined sedating antihistamine and high pollen exposures among subjects with physician and self-diagnosed allergic rhinitis (OR: 2.41). Direct medical costs associated with this increased risk were estimated at $143 million in 2001. CONCLUSIONS:
|
Authors | L P Hanrahan, L C Paramore |
Journal | American journal of industrial medicine
(Am J Ind Med)
Vol. 44
Issue 4
Pg. 438-46
(Oct 2003)
ISSN: 0271-3586 [Print] United States |
PMID | 14502773
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Copyright | Copyright 2003 Wiley-Liss, Inc. |
Chemical References |
- Air Pollutants
- Allergens
- Bronchodilator Agents
- Histamine H1 Antagonists
- Hypnotics and Sedatives
|
Topics |
- Adult
- Air Pollutants
(analysis)
- Allergens
(analysis)
- Bronchodilator Agents
(administration & dosage, adverse effects)
- Case-Control Studies
- Comorbidity
- Drug Utilization
(statistics & numerical data)
- Environmental Exposure
(statistics & numerical data)
- Environmental Monitoring
(statistics & numerical data)
- Epidemiological Monitoring
- Female
- Histamine H1 Antagonists
(administration & dosage, adverse effects)
- Humans
- Hypnotics and Sedatives
(administration & dosage, adverse effects, economics)
- Interviews as Topic
- Male
- Middle Aged
- Midwestern United States
(epidemiology)
- Multivariate Analysis
- Occupational Diseases
(economics, epidemiology)
- Pollen
- Population Surveillance
- Prevalence
- Rhinitis, Allergic, Perennial
(drug therapy, economics, epidemiology)
- Risk Factors
- Sleep Wake Disorders
(chemically induced, epidemiology)
- Wounds and Injuries
(economics, epidemiology)
|