The tricyclic antidepressant clomipramine increases plasma glucose levels of mice.

Abstract

Effects of the tricyclic antidepressant clomipramine on plasma glucose levels in mice were studied. Clomipramine at doses ranging 5 - 20 mg/kg elicited significant hyperglycemia in mice. Hyperglycemia elicited by clomipramine was not reduced by pretreatment with the 5-hydroxytryptamine (5-HT) depleter p-chlorophenylalanine. The 5-HT(1/2/5/7)-receptor antagonist methysergide and the 5-HT(2A/2B/2C)-receptor antagonist LY 53857 enhanced clomipramine-induced hyperglycemia, while the 5-HT(1A/1B)-receptor antagonist (-)-propranolol and the 5-HT(3/4)-receptor antagonist tropisetron did not affect it. The 5-HT(2B/2C)-receptor antagonist SB 206553 facilitated hyperglycemia induced by clomipramine, although the 5-HT(2A)-receptor antagonist ketanserin was without effect. Clomipramine-induced hyperglycemia was reduced by prior adrenalectomy. These results suggest that clomipramine induces hyperglycemia in mice by blocking the 5-HT(2B )and/or 5-HT(2C) receptors, which results in facilitation of adrenaline release.

• Authors: Yumi Sugimoto, Kiyo Inoue, Jun Yamada
• Journal: Journal of pharmacological sciences (J Pharmacol Sci) Vol. 93 Issue 1 Pg. 74-9 (Sep 2003) ISSN: 1347-8613 [Print] Japan
• PMID: 14501155 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antidepressive Agents, Tricyclic
• Blood Glucose
• Serotonin Agents
• Clomipramine

Topics

• Adrenalectomy
• Animals
• Antidepressive Agents, Tricyclic (pharmacology)
• Blood Glucose (metabolism)
• Clomipramine (pharmacology)
• Dose-Response Relationship, Drug
• Hyperglycemia (blood, physiopathology)
• Male
• Mice
• Serotonin Agents (pharmacology)