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Studies on cerebral protective agents. II. Novel 4-arylpyrimidine derivatives with anti-anoxic and anti-lipid peroxidation activities. (2).

Abstract
In a search for new cerebral protective agents with anti-anoxic (AA) and anti-lipid peroxidation (ALP) activities, a series of 4-arylpyrimidines, bearing an amino moiety in the C-5 position of the pyrimidine nucleus, was synthesized and tested for AA and ALP activities. Among them, 6-methyl-5-(4-methylpiperazin-1-ylcarbonyl)-4-(3-nitrophenyl )-2-phenylpyrimidin e (41, FK360) was most effective on both assays and on arachidonate-induced cerebral edema in rats. Structure-activity relationships in regard to AA activity of this series of compounds are also discussed.
AuthorsA Kuno, Y Sugiyama, K Katsuta, H Sakai, H Takasugi
JournalChemical & pharmaceutical bulletin (Chem Pharm Bull (Tokyo)) Vol. 40 Issue 9 Pg. 2423-31 (Sep 1992) ISSN: 0009-2363 [Print] Japan
PMID1446365 (Publication Type: Journal Article)
Chemical References
  • Pyrimidines
Topics
  • Animals
  • Hypoxia, Brain (drug therapy)
  • Lethal Dose 50
  • Lipid Peroxidation (drug effects)
  • Mice
  • Mice, Inbred ICR
  • Pyrimidines (chemical synthesis, pharmacology, toxicity)
  • Rats
  • Structure-Activity Relationship

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