[Activity of antioxidants in serum of animals with experimental crush syndrome].

Abstract

Ischemia of soft tissues in crush syndrome results in activation of free radical oxidation processes, which negatively effect the functions of many biological systems. The presence of antioxidant system in the body can inhibit the action of free radicals. Antiradical effect of this system is seen in vitamin K, ubiquinone and ascorbic acid. The results of the experiment showed that the quantity of vitamin K, ubiquinone and ascorbic acid increases in the serum of blood after decompression of soft tissues in 14 hours, three and seven days. This fact supports an active participation of antioxidant system in the pathogenesis of crush syndrome.

• Authors: A V Efremov, O M Belkina, A A Zykov
• Journal: Biulleten' eksperimental'noi biologii i meditsiny (Biull Eksp Biol Med) Vol. 113 Issue 6 Pg. 598-9 (Jun 1992) ISSN: 0365-9615 [Print] Russia (Federation)
• Vernacular Title: Aktivnost' antioksidantov v syvorotke krovi s éksperimental'nym sindromom dlitel'nogo sdavlivaniia.
• PMID: 1446025 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Free Radicals
• Vitamin K
• Ubiquinone
• Ascorbic Acid

Topics

• Animals
• Ascorbic Acid (blood)
• Crush Syndrome (blood, etiology)
• Free Radicals
• Male
• Rats
• Rats, Wistar
• Time Factors
• Ubiquinone (blood)
• Vitamin K (blood)