[Interferon type I in protective body reactions in an experimental Klebsiella infection].

Abstract

The study on mice with experimental generalized Klebsiella infection, carried out with the use of microbiologic, immunologic and pathomorphologic methods, revealed that the intraperitoneal injection of type I interferon into the animals prevented their death and led to the rapid elimination of the infective agent from their body, enhanced the phagocytic and metabolic activity of polymorphonuclear lymphocytes of their peritoneal exudate, decreased the manifestation of microcirculatory and dystrophic changes in the parenchyma of their internal organs.

• Authors: I V Fil'chakov, L V Avdeeva, Iu N Anisimova, E I Protsap, N Ia Spivak
• Journal: Zhurnal mikrobiologii, epidemiologii i immunobiologii (Zh Mikrobiol Epidemiol Immunobiol) Issue 2 Pg. 62-4 (Feb 1992) ISSN: 0372-9311 [Print] Russia (Federation)
• Vernacular Title: Interferon tipa I v zashchitnykh reaktsiiakh organizma pri éksperimental'noĭ klebsielleznoĭ infektsii.
• PMID: 1441818 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Interferon Type I

Topics

• Animals
• Drug Evaluation, Preclinical
• Injections, Subcutaneous
• Interferon Type I (administration & dosage)
• Klebsiella Infections (immunology, microbiology, therapy)
• Klebsiella pneumoniae (isolation & purification)
• Mice
• Mice, Inbred Strains
• Neutrophils (drug effects, immunology)
• Opportunistic Infections (immunology, microbiology, therapy)
• Phagocytosis (drug effects, immunology)
• Time Factors