[Structural components and activity of erythrocyte membrane ATPase from albino male rats under the effect of noise and simultaneous treatment with the synthetic antioxidant 3,5-ditertbutyl-4-hydroxyphenylpropanol (gamma-propanol)].

Abstract

Repeated administration of synthetic antioxidant gamma-propanol, 3,5-ditertbutyl-4-hydroxyphenyl propanol, into rats under conditions of acoustic noise led to increase in content of phospholipids, to decrease in cholesterol level simultaneously with inhibition of ATPase activity in erythrocyte membranes. The initial hypocholesterolemic effect of gamma-propanol under conditions of acute acoustic stress was replaced by hypercholesterolemia in long-term experiments within more than 4 weeks.

• Authors: M M Melkonian, K G Karagezian
• Journal: Voprosy meditsinskoi khimii (Vopr Med Khim) 1992 Jan-Feb Vol. 38 Issue 1 Pg. 46-8 ISSN: 0042-8809 [Print] Russia (Federation)
• Vernacular Title: Strukturnye komponenty i aktivnost' ATFaz membran éritrotsitov belykh krys-samtsov pod deĭstviem shuma na fone vvedeniia sinteticheskogo antioksidanta 3,5-ditertbutil-4-gidroksifenilpropanol (gamma-propanol).
• PMID: 1441295 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antioxidants
• Membrane Lipids
• Phenols
• Phospholipids
• Propanols
• gamma-propanol
• 1-Propanol
• Cholesterol
• Adenosine Triphosphatases

Topics

• 1-Propanol (pharmacology)
• Adenosine Triphosphatases (blood)
• Animals
• Antioxidants (pharmacology)
• Cholesterol (blood)
• Erythrocyte Membrane (drug effects, enzymology, metabolism)
• Male
• Membrane Lipids (blood)
• Noise
• Phenols (pharmacology)
• Phospholipids (blood)
• Propanols
• Rats