Abstract |
In a two-year prospective therapeutic trial 13 patients with systemic sclerosis (SSc) were treated with penicillamine, 9 with cyclofenil, and 7 with neither. At entry skin involvement and esophageal, lung, heart, and kidney function did not differ significantly between the groups. Reevaluation after one and two years did not show any significant changes in skin, esophageal, heart, and kidney manifestations, while lung function had slightly improved in both drug-treatment groups. This study thus shows little overall effect of penicillamine and cyclofenil, although both drugs may arrest worsening of pulmonary dysfunction.
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Authors | A Akesson, B Blom-Bülow, A Scheja, P Wollmer, S Valind, F A Wollheim |
Journal | Scandinavian journal of rheumatology
(Scand J Rheumatol)
Vol. 21
Issue 5
Pg. 238-44
( 1992)
ISSN: 0300-9742 [Print] England |
PMID | 1439632
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adult
- Aged
- Cyclofenil
(adverse effects, standards, therapeutic use)
- Electrocardiography
- Esophagus
(drug effects, physiology)
- Exercise
(physiology)
- Female
- Heart
(drug effects, physiology)
- Humans
- Immune System
(physiology)
- Kidney
(drug effects, physiology)
- Lung
(drug effects, physiology)
- Male
- Middle Aged
- Penicillamine
(adverse effects, standards, therapeutic use)
- Prospective Studies
- Scleroderma, Systemic
(drug therapy, epidemiology, physiopathology)
- Skin
(drug effects, pathology)
- Time Factors
- Ventilation-Perfusion Ratio
(physiology)
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