The efficacy of Arthrotec in the treatment of osteoarthritis.

Abstract

In a double-blind study, 455 patients with osteoarthritis were randomly assigned to receive a combination of Arthrotec, 50 mg of diclofenac and 200 micrograms of misoprostol, or 50 mg of diclofenac; the drugs were given two or three times daily for 4 weeks. At weeks 2 and 4 of treatment, no significant differences between the treatment groups were noted in changes from baseline on the physicians' and patients' global assessment of osteoarthritis. On a measure of arthritis severity, patients with both arthritis of the hip and knee showed improvement from week 2 to week 4, with no significant differences between treatment groups.

• Authors: M Doherty
• Journal: Scandinavian journal of rheumatology. Supplement (Scand J Rheumatol Suppl) Vol. 96 Pg. 15-21 ( 1992) ISSN: 0301-3847 [Print] Norway
• PMID: 1439620 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Drug Combinations
• Misoprostol
• Diclofenac

Topics

• Administration, Oral
• Adult
• Aged
• Aged, 80 and over
• Diclofenac (administration & dosage, standards, therapeutic use)
• Dose-Response Relationship, Drug
• Double-Blind Method
• Drug Combinations
• Female
• Hip Joint (physiology)
• Humans
• Knee Joint (physiology)
• Male
• Middle Aged
• Misoprostol (administration & dosage, standards, therapeutic use)
• Osteoarthritis (drug therapy)
• Severity of Illness Index