Abstract |
The partial mitotic inhibition caused by 6-mercaptopurine in tissue cultures of Crocker mouse sarcoma 180 and embryonic mouse skin is blocked by co- enzyme A. 6-Mercaptopurine and coenzyme A also have opposite effects on mitochondrial morphology. Mitochondria in cells treated with 6-mercaptopurine become thin and fragmented. Coenzyme A blocks this effect, and alone coenzyme A makes for longer and thicker mitochondria. 6-Mercaptopurine inhibits lipogenesis in embryo skin fibroblasts, and this inhibition is partly counteracted by coenzyme A, which by itself makes for a greater accumulation of lipid droplets in the cytoplasm. It is suggested that at least one part of the action by which 6-mercaptopurine decreases mitotic incidence in tissue cultures may be an interference on the part of 6-mercaptopurine, acting as an antimetabolite of coenzyme A, in mitochondrial function related to cell division.
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Authors | J J BIESELE |
Journal | The Journal of biophysical and biochemical cytology
(J Biophys Biochem Cytol)
Vol. 1
Issue 2
Pg. 119-26
(Mar 1955)
ISSN: 0095-9901 [Print] United States |
PMID | 14381434
(Publication Type: Journal Article)
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Chemical References |
- Antimetabolites
- Coenzymes
- Purines
- Mercaptopurine
- Coenzyme A
- purine
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Topics |
- Animals
- Antimetabolites
- Cell Division
- Coenzyme A
- Coenzymes
- Cytoplasm
- Fibroblasts
- Mercaptopurine
- Mice
- Mitochondria
- Mitosis
- Purines
(pharmacology)
- Sarcoma 180
- Tissue Culture Techniques
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