[The number and affinity of fibrinogen receptors in blood platelets of patients with ischemic stroke].

Abstract

Parameters of fibrinogen binding with blood platelets (number of receptors and their affinity) have been studied in patients with ischemic stroke. Due to the increased platelet ability to aggregate in the ischemic diseases such studies seem helpful. The studies involved 13 patients with ischemic stroke. Blood platelets collected from younger patients (under 50 years) possessed significantly higher number of receptors binding fibrinogen than blood platelets of healthy individuals (p less than 0.02). These receptors significantly more strongly bound ligand than those in the control group (p less than 0.05), and in the group of older patients with stroke (less than 0.05). Fibrinogen binding to blood platelets in patients over 50 years of age did not differ significantly from that in the control group. These results may indicate, that the increased platelet aggregation might be a significant pathogenic factor of the stroke in younger patients.

• Authors: W Kozubski, A Janiak, J Krzesłowska, C S Cierniewski
• Journal: Polski tygodnik lekarski (Warsaw, Poland : 1960) (Pol Tyg Lek) 1992 Apr 6-13 Vol. 47 Issue 14-15 Pg. 305-7 ISSN: 0032-3756 [Print] Poland
• Vernacular Title: Liczba i powinowactwo receptorów dla fibrynogenu w krwinkach płytkowych chorych na niedokrwienny udar mózgu.
• PMID: 1437737 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Platelet Membrane Glycoproteins
• Fibrinogen

Topics

• Adult
• Age Factors
• Binding Sites (physiology)
• Blood Platelets (metabolism)
• Brain Ischemia (blood, complications)
• Cerebral Infarction (blood, etiology)
• Female
• Fibrinogen (metabolism)
• Humans
• Male
• Middle Aged
• Platelet Membrane Glycoproteins (analysis, metabolism)
• Reference Values