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Metronidazole.

AbstractMetronidazole has proven to be a useful and inexpensive antibiotic for the treatment of T. vaginalis and bacterial vaginosis. Few alternatives exist for these two specific indications, and metronidazole will continue to play a primary role in therapy. Oral metronidazole continues to be a very inexpensive alternative to oral vancomycin for the treatment of C. difficile-induced pseudomembranous colitis. For the treatment of moderate to severe mixed aerobic/anaerobic pelvic infections, metronidazole should be considered secondarily in patients who have failed other multiple- or single-drug regimens or in patients who are infected. with anaerobic organisms resistant to other commonly used agents including clindamycin, cefoxitin, cefotetan, or ampicillin/sulbactam. Metronidazole is not a first line drug of choice for antibiotic prophylaxis in obstetric and gynecologic patients.
AuthorsW D Hager, R P Rapp (Affiliation: Department of Obstetrics and Gynecology, University of Kentucky School of Medicine, Lexington.)
JournalObstetrics and gynecology clinics of North America (Obstet Gynecol Clin North Am) Vol. 19 Issue 3 Pg. 497-510 (Sep 1992) ISSN: 0889-8545 UNITED STATES
PMID1436927 (Publication Type: Journal Article, Review)
Chemical References
  • Metronidazole
Topics
  • Bacterial Infections (drug therapy)
  • Costs and Cost Analysis
  • Drug Interactions
  • Drug Resistance, Microbial
  • Enterocolitis, Pseudomembranous (drug therapy)
  • Female
  • Genital Diseases, Female (drug therapy)
  • Humans
  • Metronidazole (adverse effects, chemistry, therapeutic use)
  • Pregnancy
  • Pregnancy Complications, Parasitic (drug therapy)
  • Trichomonas Vaginitis (drug therapy)
  • Vaginosis, Bacterial (drug therapy)