[Clonorchiasis in the People's Republic of Vietnam. 2. The clinico-parasitological examination of a focus and a trial of prazinquantel treatment].

Abstract

Examinations of 1599 residents of a polyinvasion focus at a seaside province Ha Nam Nin, Vietnam, have revealed clonorchiasis in approximately 13.9% of the examinees; in subjects aged over 30 this value was 29.3%. Factors conducive to a lower incidence of clonorchiasis were detected, among them a moderate intensity of the invasion: the mean arithmetic was 1419 +/- 306 eggs/g, the mean geometric 673 egg/g, as shown by the Kato-Kats' technique. Analysis of five therapeutic schemes used in clonorchiasis, making use of chloxilin, medamin or praziquantel, has demonstrated a low efficacy of all of them. Praziquantel therapy in a daily dose of 25 mg/kg for 2 days was found the most effective (52%), being conducive to a reduction of the invasion intensity by at least 90%. Such therapy was associated with a high incidence of side effects (91.2%), this ruling out a higher dosage.

• Authors: T L Kieu, A M Bronshteĭn, T P Sabgaĭda
• Journal: Meditsinskaia parazitologiia i parazitarnye bolezni (Med Parazitol (Mosk)) 1992 Jul-Aug Issue 4 Pg. 7-11 ISSN: 0025-8326 [Print] Russia (Federation)
• Vernacular Title: Klonorkhoz v SRV. Soobshchenie 2. Kliniko-parazitologicheskoe obsledovanie ochaga i opyt lecheniia prazikvantelem.
• PMID: 1435590 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, English Abstract, Journal Article)

Chemical References

• Antiplatyhelmintic Agents
• Benzimidazoles
• Carbamates
• Xylenes
• Praziquantel
• hexachloro-4-xylene
• carbendazim

Topics

• Adult
• Animals
• Antiplatyhelmintic Agents (therapeutic use)
• Benzimidazoles (therapeutic use)
• Carbamates
• Clonorchiasis (drug therapy, parasitology)
• Clonorchis sinensis
• Disease Reservoirs
• Drug Evaluation
• Feces (parasitology)
• Humans
• Parasite Egg Count
• Praziquantel (adverse effects, therapeutic use)
• Rural Population
• Vietnam
• Xylenes (therapeutic use)