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Humoral hypercalcemia associated with a dysgerminoma.

Abstract
A 16-year-old girl sought medical attention at the Mayo Clinic because of a 4.5-kg weight loss, hypercalcemia, and a pelvic mass. Preoperatively, the level of the beta-subunit of human chorionic gonadotropin was 147 IU/liter. After a brief period for observation and hydration, abdominal exploration revealed a stage III dysgerminoma; total abdominal hysterectomy and bilateral salpingo-oophorectomy were performed. Within the dysgerminoma, syncytial giant cells expressed human chorionic gonadotropin-positive immunostaining in the cytoplasm. Postoperatively, the value of the beta-subunit of human chorionic gonadotropin decreased rapidly. The patient received whole-abdomen irradiation 4 weeks postoperatively, after which the level of calcium returned to normal. The patient has been free of disease for more than 7 years.
AuthorsS C Giebel, C R Stanhope, G D Malkasian Jr, M F Schray, H Heath 3rd, T A Gaffey
JournalMayo Clinic proceedings (Mayo Clin Proc) Vol. 67 Issue 10 Pg. 966-8 (Oct 1992) ISSN: 0025-6196 [Print] England
PMID1434857 (Publication Type: Case Reports, Journal Article)
Topics
  • Adolescent
  • Combined Modality Therapy
  • Dysgerminoma (complications, radiotherapy, surgery)
  • Female
  • Humans
  • Hypercalcemia (etiology)
  • Ovarian Neoplasms (complications, radiotherapy, surgery)

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