[Acid-base balance disorder in various diseases--diabetes mellitus].

Abstract

Metabolic acidosis is the serious acid-base balance disorder complicated in diabetes mellitus. The pathogenesis and treatment of various type of metabolic acidosis (Keto-acidosis, lactic acidosis, hyperchloremic acidosis and type IV renal tubular acidosis) are discussed. Metabolic acidosis in the diabetic patient is associated with an increased anion-gap caused by the presence of organic anion (beta-hydroxybutyrate, acetoacetate, and lactate). The rise in anion-gap usually equals the fall in plasma bicarbonate. With appropriate therapy, progressive decline in the anion-gap is one of the best indications of successful treatment. If hyperchloremic acidosis is established, appropriate infusion of hypochloremic rehydration fluid may be useful.

• Authors: T Yoshimi
• Journal: Nihon rinsho. Japanese journal of clinical medicine (Nihon Rinsho) Vol. 50 Issue 9 Pg. 2206-12 (Sep 1992) ISSN: 0047-1852 [Print] Japan
• PMID: 1434013 (Publication Type: English Abstract, Journal Article, Review)

Topics

• Acidosis, Lactic (etiology)
• Diabetes Complications
• Diabetic Ketoacidosis (metabolism)
• Humans