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REGULATION OF ASCORBIC ACID AND OF XYLULOSE SYNTHESIS IN RAT-LIVER EXTRACTS. THE EFFECT OF STARVATION ON THE ENZYMES OF THE GLUCURONIC ACID PATHWAY.

Abstract
1. The synthesis of ascorbic acid in rat-liver extracts is impaired during starvation, and more from glucuronolactone and glucuronate than from gulonate and gulonolactone. 2. The formation of xylulose from gulonate and from gulonolactone is greatly enhanced during starvation, whereas it is decreased from glucuronolactone and from glucuronate. 3. The activity of the enzymes of the glucuronic acid pathway during starvation has been determined in rat-liver preparations. Gulonolactone oxidase is decreased, NAD-linked gulonate dehydrogenase is enhanced, and uronolactonase, aldonolactonase and NADP-linked hexonate dehydrogenase are unchanged. 4. The impairment of ascorbic acid synthesis from gulonate observed during starvation can be accounted for by the depressed activity of gulonolactone oxidase. 5. The cause of the enhanced formation of xylulose has been located in the sedimentable fraction of liver homogenate. 6. The hypothesis is formulated of an increased utilization of the glucuronic acid pathway during starvation.
AuthorsF STIRPE, M COMPORTI
JournalThe Biochemical journal (Biochem J) Vol. 95 Pg. 354-62 (May 1965) ISSN: 0264-6021 [Print] England
PMID14340084 (Publication Type: Journal Article)
Chemical References
  • Glucuronates
  • Lactones
  • Liver Extracts
  • Pentoses
  • Sugar Acids
  • gulonic acid
  • glucuronolactone
  • gulonolactone
  • NADP
  • Xylulose
  • Glucuronic Acid
  • Oxidoreductases
  • Alcohol Oxidoreductases
  • Carbohydrate Dehydrogenases
  • L-glucuronate reductase
  • gulonate dehydrogenase
  • Esterases
  • uronolactonase
  • Ascorbic Acid
Topics
  • Alcohol Oxidoreductases
  • Ascorbic Acid
  • Carbohydrate Dehydrogenases
  • Carbohydrate Metabolism
  • Esterases
  • Glucuronates
  • Glucuronic Acid
  • Lactones
  • Liver
  • Liver Extracts
  • Metabolism
  • NADP
  • Oxidoreductases
  • Pentoses
  • Rats
  • Research
  • Starvation
  • Sugar Acids
  • Xylulose

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