Abstract |
The xanthine derivative propentofylline ( HWA 285) has been reported to show protective effects against neuronal damage induced by cerebral ischemia. In the present study, we investigated the effect of propentofylline on the hypoxia- hypoglycemia-induced intracellular calcium accumulation in gerbil hippocampal slices using microfluorometry. When slices were superfused with hypoxic- hypoglycemic medium that did not contain propentofylline, an acute increase in calcium accumulation was detected 75-200s (mean latency of 123s) after the start of hypoxic- hypoglycemia. When slices were superfused with hypoxic- hypoglycemic medium that contained 10 microM, 100 microM and 1mM propentofylline, the latency period before acute increase in calcium accumulation was prolonged in all subregions of the hippocampus in a dose-dependent manner: mean latencies in field CA 1 were 146, 168, and 197s after hypoxic- hypoglycemia, respectively. This retardation in calcium accumulation may be involved in the mechanisms by which propentofylline diminishes ischemic injury.
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Authors | F Kadoya, A Mitani, K Kataoka, T Arai |
Journal | Masui. The Japanese journal of anesthesiology
(Masui)
Vol. 41
Issue 10
Pg. 1610-6
(Oct 1992)
ISSN: 0021-4892 [Print] Japan |
PMID | 1433835
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Culture Media
- Xanthines
- propentofylline
- Glucose
- Calcium
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Topics |
- Animals
- Calcium
(metabolism)
- Cell Hypoxia
(physiology)
- Culture Media
- Cytophotometry
- Gerbillinae
- Glucose
- Hippocampus
(drug effects, metabolism)
- In Vitro Techniques
- Xanthines
(pharmacology)
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