Intravenous glutamine fails to improve gut morphology after radiation injury.

Abstract

Male Sprague-Dawley rats housed in individual metabolic cages received total parenteral nutrients via chronic indwelling internal jugular catheters to determine whether supplementing parenteral nutrition with glutamine would accelerate recovery of small-bowel morphology after abdominal radiation. After recovering from catheter insertion for 3 days they received either 1000 cGy gamma radiation to the abdomen only or no radiation and immediately thereafter received isonitrogenous and isocaloric intravenous solutions containing either 0% or 2% glutamine at 1.58 mL/h for the next 5 days. Intestinal segments were then assayed for whole-bowel deoxyribose nucleic acid content and villus height. Irradiation caused a 40% decrement in these parameters, which were not restored by glutamine supplementation. Therefore, intravenous glutamine supplementation failed to accelerate recovery of small-bowel morphology in this model of combined surgical and radiation injury.

• Authors: T E Scott, J R Moellman
• Journal: JPEN. Journal of parenteral and enteral nutrition (JPEN J Parenter Enteral Nutr) 1992 Sep-Oct Vol. 16 Issue 5 Pg. 440-4 ISSN: 0148-6071 [Print] United States
• PMID: 1433777 (Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Glutamine
• DNA

Topics

• Animals
• DNA (analysis)
• Glutamine (administration & dosage, therapeutic use)
• Injections, Intravenous
• Intestines (injuries, pathology, radiation effects)
• Male
• Parenteral Nutrition, Total
• Radiation Injuries, Experimental (pathology, therapy)
• Rats
• Rats, Sprague-Dawley
• Time Factors