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Lactimidomycin, a new glutarimide group antibiotic. Production, isolation, structure and biological activity.

Abstract
Streptomyces amphibiosporus R310-104 (ATCC 53964) produced a novel antibiotic lactimidomycin which showed inhibitory activity against fungi and prolonged the survival time of mice transplanted with experimental tumors. Structural studies clarified that lactimidomycin is a new glutarimide antibiotic having a unique unsaturated 12-membered lactone ring.
AuthorsK Sugawara, Y Nishiyama, S Toda, N Komiyama, M Hatori, T Moriyama, Y Sawada, H Kamei, M Konishi, T Oki
JournalThe Journal of antibiotics (J Antibiot (Tokyo)) Vol. 45 Issue 9 Pg. 1433-41 (Sep 1992) ISSN: 0021-8820 [Print] England
PMID1429229 (Publication Type: Journal Article)
Chemical References
  • Antibiotics, Antineoplastic
  • Antifungal Agents
  • Macrolides
  • Piperidones
  • lactimidomycin
Topics
  • Animals
  • Antibiotics, Antineoplastic (chemistry, isolation & purification, pharmacology)
  • Antifungal Agents (chemistry, isolation & purification, pharmacology)
  • Female
  • Macrolides
  • Magnetic Resonance Spectroscopy
  • Male
  • Mice
  • Microbial Sensitivity Tests
  • Neoplasms, Experimental (drug therapy)
  • Piperidones (chemistry, isolation & purification, pharmacology)
  • Streptomyces (chemistry)

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