Abstract |
Treatment of superficial bladder carcinoma in situ with Connaught BCG ( ImmuCyst) significantly increased complete response rate and extended the disease-free interval when compared with Doxorubicin (DOX) chemotherapy. In 54 patients treated with ImmuCyst, 74% showed complete response compared with 42% of 60 patients treated with DOX. The median disease-free time was 48.2 months for BCG and 5.9 months for DOX treatment. Types and severity of adverse reactions were similar for both treatments and within tolerable ranges.
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Authors | L Barreto, Z Csizer, J D Sparkes |
Journal | Developments in biological standardization
(Dev Biol Stand)
Vol. 77
Pg. 229-31
( 1992)
ISSN: 0301-5149 [Print] Switzerland |
PMID | 1426667
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- BCG Vaccine
- Vaccines, Attenuated
- Doxorubicin
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Topics |
- Administration, Intravesical
- Aged
- BCG Vaccine
(administration & dosage, adverse effects, therapeutic use)
- Carcinoma in Situ
(drug therapy, therapy)
- Carcinoma, Transitional Cell
(drug therapy, mortality, therapy)
- Doxorubicin
(administration & dosage, adverse effects, therapeutic use)
- Fever
(etiology)
- Follow-Up Studies
- Humans
- Middle Aged
- Neoplasm Recurrence, Local
(prevention & control)
- Neoplasms, Multiple Primary
(mortality)
- Survival Analysis
- Urinary Bladder Neoplasms
(drug therapy, mortality, therapy)
- Urologic Diseases
(etiology)
- Vaccines, Attenuated
(administration & dosage, adverse effects, therapeutic use)
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