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Pregnenolone sulfate increases the convulsant potency of N-methyl-D-aspartate in mice.

Abstract
The neurosteroid pregnenolone sulfate is known to specifically enhance NMDA-gated currents in spinal cord neurons. The response does not appear to be mediated by the glycine/NMDA modulatory site. Here we found that pregnenolone sulfate significantly increased the convulsant potency of N-methyl-D-aspartate (NMDA), but not of pentylenetetrazol (PTZ). In agreement with previous in vitro reports showing that the glutamergic NMDA receptor is also specifically modulated by steroids, our findings suggest that pregnenolone sulfate selectively activates the NMDA receptors involved in convulsions in the intact animal.
AuthorsS Maione, L Berrino, S Vitagliano, J Leyva, F Rossi
JournalEuropean journal of pharmacology (Eur J Pharmacol) Vol. 219 Issue 3 Pg. 477-9 (Sep 04 1992) ISSN: 0014-2999 [Print] Netherlands
PMID1425973 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Receptors, N-Methyl-D-Aspartate
  • pregnenolone sulfate
  • N-Methylaspartate
  • Pregnenolone
  • Pentylenetetrazole
Topics
  • Animals
  • Dose-Response Relationship, Drug
  • Drug Synergism
  • Injections, Intraperitoneal
  • Male
  • Mice
  • N-Methylaspartate (administration & dosage, pharmacology)
  • Pentylenetetrazole (administration & dosage, pharmacology)
  • Pregnenolone (pharmacology)
  • Receptors, N-Methyl-D-Aspartate (drug effects)
  • Seizures (chemically induced)

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