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[Importance of hypergastrinemia in diagnosis of Biermer's disease in adults].

Abstract
Achlorhydria that is due to antrum sparing atrophic gastritis is a characteristic finding in pernicious anemia. As a consequence of this achlorhydria serum gastrin level rise. Usually several signs are required for assessing a pernicious anemia: megaloblastic anemia, low serum cobalamin level, positivity of a Schilling test, low level of intrinsic factor in the gastric juice, existence of anti-intrinsic factor antibodies in plasma and/or in gastric juice. In this study the usefulness of the serum gastrin level is assessed. We report here the results in investigating sixteen patients with a pernicious anemia. All had: megaloblastic changes on bone marrow examination, serum cobalamin level lower than 150 pg/ml. For 14 patients the performed Schilling test was positive. For 2, no Schilling test was done, but anti-intrinsic factor antibodies were elevated. Serum gastrin levels were higher than 250 pg/ml (254 to 1770 pg/ml). In our patients with pernicious anemia, as a result of hypo or achlorhydria, serum gastrin increase was higher than in any other cause of hypochlohydria: anti-acid treatment, vagotomy... Measurement of serum gastrin is easy. High levels are simple to explain if found together with a sparing antrum atrophic gastritis and/or a low level of serum cobalamin. Serum gastrin measurement may be a cornerstone to rapid and reliable diagnosis of pernicious anemia.
AuthorsM Mongin, J R Harle, P J Weiller
JournalBulletin de l'Académie nationale de médecine (Bull Acad Natl Med) Vol. 176 Issue 5 Pg. 693-700 (May 1992) ISSN: 0001-4079 [Print] FRANCE
Vernacular TitlePlace de l'hypergastrinémie dans le diagnostic de la maladie de Biermer de l'adulte.
PMID1422872 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Gastrins
Topics
  • Adult
  • Anemia, Pernicious (blood, diagnosis)
  • Gastrins (blood)
  • Humans

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