Wegener's granulomatosis in a patient with a rheumatoid arthritis.

Abstract

A 38-year-old woman with rheumatoid arthritis who developed Wegener's granulomatosis is described. Wegener's granulomatosis appeared with saddle nose, perforation in her nasal septum, and granuloma in the nasal cavity. Laboratory evaluation showed a positive rheumatoid factor and circulating immune complex. Radiographic examination revealed ankylotic changes in both wrist and elbow joints. Bilateral anosmia and other disease manifestations completely responded to treatment with oral cyclophosphamide and prednisolone.

• Authors: H Ohashi, M Itoh, N Ogawa, Y Sudo, S Endo, T Okugawa, H Ito, H Mineta, M Nozue
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 31 Issue 9 Pg. 1128-31 (Sep 1992) ISSN: 0918-2918 [Print] Japan
• PMID: 1421723 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antigen-Antibody Complex
• Cyclophosphamide
• Rheumatoid Factor
• Prednisolone

Topics

• Adult
• Antigen-Antibody Complex (blood)
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Arthritis, Rheumatoid (complications)
• Cyclophosphamide (administration & dosage)
• Female
• Granulomatosis with Polyangiitis (complications, drug therapy, pathology)
• Humans
• Olfaction Disorders (drug therapy, etiology)
• Prednisolone (administration & dosage)
• Rheumatoid Factor (blood)