[Anticalcium activity of several antidepressive agents].

Abstract

In experiments in white mice and rats the antidepressants pyrazidol (pirlindole), moclobemide and especially tetrindole possess anticalcium activity in tests of calcium chloride-induced lethality in mice and arrhythmia in rats. Tetrindole is as active as verapamil. Imipramine, azaphen and incazane were not active in these experiments. In vitro on isolated intestinal segments of guinea-pigs tetrindole exerts anticalcium action, but in less degree than verapamil. In all probability the anticalcium activity of tetrindole may play some role in the mechanism of action of this compound on the central nervous system.

• Authors: N I Andreeva, S M Golovina, E A Rumiantsev, M D Mashkovskiĭ
• Journal: Biulleten' eksperimental'noi biologii i meditsiny (Biull Eksp Biol Med) Vol. 113 Issue 5 Pg. 502-4 (May 1992) ISSN: 0365-9615 [Print] Russia (Federation)
• Vernacular Title: Issledovanie antikal'tsievogo deĭstviia nekotorykh antidepressantov.
• PMID: 1421269 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Antidepressive Agents
• Antidepressive Agents, Tricyclic
• Benzamides
• Carbazoles
• Oxazines
• azaphen
• Verapamil
• Calcium Chloride
• Imipramine
• Moclobemide
• Calcium
• pirlindole

Topics

• Animals
• Antidepressive Agents (pharmacology)
• Antidepressive Agents, Tricyclic (pharmacology)
• Arrhythmias, Cardiac (chemically induced)
• Benzamides (pharmacology)
• Brain (drug effects)
• Calcium (antagonists & inhibitors)
• Calcium Chloride (adverse effects)
• Carbazoles (pharmacology)
• Female
• Imipramine (pharmacology)
• Male
• Mice
• Moclobemide
• Oxazines (pharmacology)
• Rats
• Verapamil (pharmacology)