[Study of axodendritic synapses of the hippocampal CA3 field in experimental uremia and administration of exogenous parathyroid hormone].

Abstract

The effect of parathyroid hormone intraperitoneal injection at different stages of experimental uremia induced by subtotal nephrectomy on ultrastructural morphofunctional characteristics of hippocampus Ca3 field axospinal synapses was studied. A conclusion is made that the decrease of synaptic activity in the hippocampus field due to redistribution of calcium ions between spine cytoplasm and spine apparatus may take place after PTH injection and during uremia development.

• Authors: V A Titova, I N Pavlenko, S M Popov, S A Zueva, V V Barabanova
• Journal: Biulleten' eksperimental'noi biologii i meditsiny (Biull Eksp Biol Med) Vol. 113 Issue 5 Pg. 469-72 (May 1992) ISSN: 0365-9615 [Print] Russia (Federation)
• Vernacular Title: Issledovanie aksoshipikovykh sinapsov polia CA3 gippokampa pri éksperimental'noĭ uremii i vvedenii ékzogennogo paratireoidnogo gormona.
• PMID: 1421253 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Parathyroid Hormone
• Calcium

Topics

• Animals
• Axons (ultrastructure)
• Calcium (metabolism)
• Dendrites (ultrastructure)
• Hippocampus (pathology)
• Injections, Intraperitoneal
• Male
• Nephrectomy
• Parathyroid Hormone (administration & dosage, pharmacology)
• Rats
• Rats, Wistar
• Synapses (ultrastructure)
• Time Factors
• Uremia (metabolism, pathology)