Abstract |
Transforming growth factor alpha ( TGF-alpha) is a single chain polypeptide which exists in a variety of forms differing in molecular weight. These forms are variously present in normal and neoplastic cells. Of particular interest are TGF-alpha's well-known mitogenic properties. The transition from a normal to a neoplastic cellular state results from signalling defects that may depend upon, inter alia, abnormal levels of expression and secretion of TGF-alpha. It is known that the secretion of TGF-alpha may be enhanced appreciably by agents such as phorbol 12-myristate 13-acetate (PMA), serum factors and epidermal growth factor ( EGF). Here, we compare the efficacy of these three agents in the elevation of TGF-alpha secretion in the well studied A431 cell line with their previously undocumented efficacy in certain interesting, but little known, human oesophageal squamous cell carcinoma (SCC) lines.
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Authors | A L Thornley, G J Jones |
Journal | Bioscience reports
(Biosci Rep)
Vol. 12
Issue 4
Pg. 293-302
(Aug 1992)
ISSN: 0144-8463 [Print] England |
PMID | 1421058
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Transforming Growth Factor alpha
- Epidermal Growth Factor
- ErbB Receptors
- Tetradecanoylphorbol Acetate
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Topics |
- Carcinoma, Squamous Cell
(metabolism)
- Epidermal Growth Factor
(pharmacology)
- ErbB Receptors
(physiology)
- Esophageal Neoplasms
(metabolism)
- Humans
- In Vitro Techniques
- Secretory Rate
(drug effects)
- Tetradecanoylphorbol Acetate
(pharmacology)
- Transforming Growth Factor alpha
(metabolism)
- Tumor Cells, Cultured
(metabolism)
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