Abstract |
This study was designed to compare the effectiveness of single doses of either Liquid Gaviscon or Algicon Suspension in the suppression of food and acid reflux into the oesophagus after a test meal in volunteers. After the pH electrode and gamma detector were positioned 5 cm above the cardia, the volunteers received a refluxogenic radiolabelled meal. The subjects then remained untreated, or thirty minutes later they were given a dose of unlabelled Algicon Suspension, or Liquid Gaviscon and a recording was made for a minimum of 3 hours. Allocation to the treatment group was randomized with the cross-overs performed 1 week apart. Liquid Gaviscon suppressed gastro-oesophageal reflux of both food and acid whereas only an insignificant reduction in reflux was seen after Algicon Suspension. The oesophageal pH remained below 4 for 3.21 +/- 0.92% (S.E.M.) of the recording period in the control study, 0.88 +/- 0.33 after Gaviscon and 2.91 +/- 0.68 after Algicon. The reflux of food was reduced from 17,070 x 10(3) +/- 4713 x 10(3) counts in the control study to 224 x 10(3) +/- 93 x 10(3) counts after the Gaviscon and 16,080 x 10(3) +/- 7131 x 10(3) counts after Algicon. The suppression of reflux by Liquid Gaviscon was significantly better than that produced by Algicon Suspension.
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Authors | N Washington, J L Greaves, S Y Iftikhar |
Journal | Alimentary pharmacology & therapeutics
(Aliment Pharmacol Ther)
Vol. 6
Issue 5
Pg. 579-88
(Oct 1992)
ISSN: 0269-2813 [Print] England |
PMID | 1420749
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Alginates
- Antacids
- Bicarbonates
- Carbonates
- Drug Combinations
- Algicon
- Silicic Acid
- Aluminum Hydroxide
- alginate, aluminium hydroxide, magnesium trisilicate, sodium bicarbonate drug combination
- Technetium
- Sodium Bicarbonate
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Topics |
- Adult
- Alginates
(therapeutic use)
- Aluminum Hydroxide
(therapeutic use)
- Ambulatory Care
(methods)
- Antacids
(therapeutic use)
- Bicarbonates
(therapeutic use)
- Calibration
- Carbonates
(therapeutic use)
- Drug Combinations
- Electrodes, Implanted
- Esophagus
(diagnostic imaging, metabolism)
- Female
- Food
- Gamma Cameras
- Gastroesophageal Reflux
(prevention & control)
- Humans
- Hydrogen-Ion Concentration
- Male
- Monitoring, Physiologic
- Radionuclide Imaging
- Silicic Acid
(therapeutic use)
- Sodium Bicarbonate
- Technetium
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