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Monoclonal antibodies in the study and therapy of hematopoietic cancers.

Abstract
Recent advances utilizing monoclonal antibodies to phenotype acute leukemias have revealed no prognostic significance of the expression of lymphoid-associated antigens by acute myeloid leukemia blasts and conflicting results regarding 'biphenotypic' acute myeloid leukemia. Several studies treating patients with refractory lymphoma with immunotoxins reported encouraging results but significant production of anti-mouse or anti-toxin antibody. Radiolabeled antibodies that react with panhematopoietic antigens have delivered selective radiation to marrow, spleen and lymph nodes in animal models and are being used in Phase I studies of marrow transplantation for acute leukemia.
AuthorsD C Matthews, F O Smith, I D Bernstein
JournalCurrent opinion in immunology (Curr Opin Immunol) Vol. 4 Issue 5 Pg. 641-6 (Oct 1992) ISSN: 0952-7915 [Print] England
PMID1418732 (Publication Type: Journal Article, Review)
Chemical References
  • Antibodies, Monoclonal
  • Immunotoxins
Topics
  • Antibodies, Monoclonal (therapeutic use)
  • Humans
  • Immunotoxins (therapeutic use)
  • Leukemia (therapy)
  • Lymphoma (therapy)
  • Prognosis
  • Radioimmunotherapy

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