PRELIMINARY REPORT ON AN IRON-SORBITOL-CITRIC ACID COMPLEX (JECTOFER), A NEW INTRAMUSCULAR IRON PREPARATION.

Abstract

One hundred and twenty-eight patients with iron deficiency anemia were treated with a new intramuscular iron preparation, iron-sorbitol-citric acid. One group of 10 patients received a total of 1000 mg. each of elemental iron intramuscularly. All obtained a rise in hemoglobin of over 2.1 g. %, an elevation of serum iron, and a reticulocyte response over 6%. A second larger group of subjects consisted of 113 prenatal and five gynecologic patients; these received an average total dose of 1050 mg. and 1020 mg., respectively, and the average increase in hemoglobin ranged from 1.6 g. % to 2.5 g. %.None of the patients developed significant side effects after injection or permanent staining at the site of injection. Three patients experienced a transient ache at the injection site, and three developed local urticaria-like reactions lasting 24 hours.This new preparation appears to be a safe and clinically effective therapeutic agent in situations in which parenteral iron is indicated.

• Authors: D C LEY, S C ROBINSON
• Journal: Canadian Medical Association journal (Can Med Assoc J) Vol. 91 Pg. 289-92 (Aug 08 1964) ISSN: 0008-4409 [Print] Canada
• PMID: 14180535 (Publication Type: Journal Article)

Chemical References

• Citrates
• Drug Combinations
• Ferric Compounds
• Hemoglobins
• citric acid, iron, sorbitol drug combination
• Citric Acid
• Sorbitol
• Iron

Topics

• Anemia
• Anemia, Hypochromic
• Anemia, Iron-Deficiency
• Citrates
• Citric Acid
• Drug Combinations
• Drug Therapy
• Ferric Compounds
• Hemoglobins
• Humans
• Injections, Intramuscular
• Iron
• Sorbitol
• Toxicology