Increase of brain endogenous monoamine oxidase inhibitory activity (tribulin) in experimental audiogenic seizures in rats: evidence for a monoamine oxidase A inhibiting component of tribulin.
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| Abstract |
Brain tribulin activity in rats with an inherited predisposition to audiogenic epilepsy was studied after seizures of different intensity were induced by an electric bell. Weak seizures (from 0 to 2 arbitrary units) did not produce any changes in endogenous inhibitory activity towards either monoamine oxidase (MAO) A or B. Moderate seizures were characterized by increases in both MAO A and MAO B inhibitory activity (up to 1.9-fold). Complete tonic epileptiform seizures with total areflexia (4 arbitrary units) induced further augmentation (up to 2.5-fold) of MAO A but not of MAO B inhibitory activity. This dissociation between the two inhibitory activities points to the existence of a separate MAO A-inhibiting component of brain tribulin which is different from isatin.
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| Authors | A E Medvedev, V Z Gorkin, I B Fedotova, A F Semiokhina, V Glover, M Sandler |
| Journal | Biochemical pharmacology (Biochem Pharmacol) Vol. 44 Issue 6 Pg. 1209-10 (Sep 25 1992) ISSN: 0006-2952 [Print] England |
| PMID | 1417943 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
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