St-93 hyperglycemia in Wistar rats.

Abstract

The alpha 2-adrenoceptor agonist St-93 was evaluated for its effect on blood glucose levels in Wistar rats. A dose-dependent increase in blood glucose was observed in rats after intraperitoneal administration of St-93. The hyperglycemic effect of St-93 was not altered by prazosin and propranolol, whereas idazoxan significantly inhibited this effect. Pretreatment with reserpine did not affect the hyperglycemic effect of St-93. There was no significant increase in the blood glucose values with St-93 in streptozotocin-diabetic rats. It may be concluded that the hyperglycemia induced by St-93 is mediated through alpha 2-adrenoceptors, possibly located on pancreatic beta-cells.

• Authors: G P Thomas, A Krishnamurthy, G S Thapar, R K Varma
• Journal: Archives internationales de pharmacodynamie et de therapie (Arch Int Pharmacodyn Ther) 1992 Jan-Feb Vol. 315 Pg. 79-86 ISSN: 0003-9780 [Print] Belgium
• PMID: 1417366 (Publication Type: Journal Article)

Chemical References

• Anti-Arrhythmia Agents
• Blood Glucose
• St 93
• Reserpine
• Clonidine

Topics

• Animals
• Anti-Arrhythmia Agents (pharmacology)
• Blood Glucose (metabolism)
• Clonidine (analogs & derivatives, antagonists & inhibitors, pharmacology)
• Diabetes Mellitus, Experimental (blood)
• Hyperglycemia (blood, chemically induced)
• Male
• Rats
• Rats, Wistar
• Reserpine (pharmacology)