In vitro activities of streptomycin and 11 oral antimicrobial agents against clinical isolates of Klebsiella rhinoscleromatis.

Abstract

We tested in vitro the activities of streptomycin and tetracycline--antibiotics that have long been used to treat rhinoscleroma--as well as several newer oral agents by using 23 isolates of the causative organism Klebsiella rhinoscleromatis. All isolates were inhibited by clinically achievable concentrations of trimethoprim-sulfamethoxazole, amoxicillin-clavulanate, chloramphenicol, ciprofloxacin, cephalexin, cefuroxime, and cefpodoxime.

• Authors: B A Perkins, R J Hamill, D M Musher, C O'Hara
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 36 Issue 8 Pg. 1785-7 (Aug 1992) ISSN: 0066-4804 [Print] United States
• PMID: 1416867 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Anti-Bacterial Agents
• Tetracyclines
• Streptomycin

Topics

• Anti-Bacterial Agents (pharmacology)
• Drug Therapy, Combination (pharmacology)
• Humans
• Klebsiella pneumoniae (drug effects)
• Microbial Sensitivity Tests
• Rhinoscleroma (microbiology)
• Streptomycin (pharmacology)
• Tetracyclines (pharmacology)