Abstract | STUDY OBJECTIVE: DESIGN: Controlled trial with all animals receiving all treatments applied to different cutaneous phenol burn sites. TYPE OF PARTICIPANTS: Swine weighing 9 to 18 kg. INTERVENTIONS: In phase 1, each burn site was treated with water rinse for zero, one, or five minutes combined with either isopropyl alcohol, polyethylene glycol with industrial methylated spirits, ethanol, or no other treatment. Biopsies of treatment sites were done at 30 minutes and at 48 hours. In phase 2, a pilot study, the effect of isopropyl alcohol, polyethylene glycol with industrial methylated spirits, or water treatment on serum phenol levels was noted in animals with 5%, 10%, and 15% body surface area burns. MEASUREMENTS AND MAIN RESULTS: In phase 1, on histological examination of biopsy specimens, significant differences in tissue damage occurred among the groups (P < .05). Isopropyl alcohol and polyethylene glycol with industrial methylated spirits were the most efficacious treatments; the duration of water rinse had no significant effect. In phase 2, the systemic absorption of phenol may be greater with water treatment than with isopropyl alcohol treatment. CONCLUSION:
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Authors | D M Hunter, B L Timerding, R B Leonard, T H McCalmont, E Schwartz |
Journal | Annals of emergency medicine
(Ann Emerg Med)
Vol. 21
Issue 11
Pg. 1303-7
(Nov 1992)
ISSN: 0196-0644 [Print] United States |
PMID | 1416322
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Phenols
- Ethanol
- Polyethylene Glycols
- 1-Propanol
- Methanol
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Topics |
- 1-Propanol
(therapeutic use)
- Animals
- Biopsy
- Burns, Chemical
(drug therapy, pathology)
- Ethanol
(therapeutic use)
- Methanol
(administration & dosage)
- Phenols
(blood, toxicity)
- Polyethylene Glycols
(administration & dosage, therapeutic use)
- Swine
- Therapeutic Irrigation
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