[Studies on the alkaloids of Cephalotaxus. IX. Semi-synthesis of cephalotaxine esters and their anti-leukemic activity].

Abstract

Harringtonine, homoharringtonine, deoxyharringtonine and isoharringtonine isolated from Cephalotaxus plant are the esters of cephalotaxine with significant inhibitory activity against P-388 leukemia. In this investigation seventeen new esters of cephalotaxine type alkaloids have been synthesized. Preliminary pharmacological examination showed that compounds 1, 2, 2 + 3, 6 and 8 showed similar antileukemic activity as homoharringtonine. Compounds 4, 5, 15 and 16 showed moderate inhibitory activity. Some structure activity correlations of these esters were discussed.

• Authors: D Z Wang, G E Ma, R S Xu
• Journal: Yao xue xue bao = Acta pharmaceutica Sinica (Yao Xue Xue Bao) Vol. 27 Issue 3 Pg. 178-84 ( 1992) ISSN: 0513-4870 [Print] China
• PMID: 1414382 (Publication Type: English Abstract, Journal Article)

Chemical References

• Harringtonines

Topics

• Animals
• Harringtonines (chemical synthesis, pharmacology)
• Leukemia P388 (pathology)
• Mice
• Tumor Cells, Cultured (drug effects)