Nucleotide and deduced amino acid sequence of the canine adenovirus type 1 proteinase.

Abstract

The DNA sequence of an open reading frame (ORF) corresponding to the canine adenovirus type 1 (Can1) proteinase gene was determined. A total of 1171 base pairs were sequenced from the downstream end of the HindIII-A Can1 genomic fragment, including adjacent regions corresponding to the carboxy-terminal portions of the hexon and the DNA-binding proteins. The predicted Can1 proteinase consists of 206 residues (23,325 D) of which 68% are identical and 83% are similar to the sequence of the human Ad2 proteinase. Alignment with the Ad2 proteinase identified a number of conserved residues that could form part of the catalytic triad of the enzyme.

• Authors: F Cai, J M Weber
• Journal: Virus genes (Virus Genes) Vol. 6 Issue 3 Pg. 307-12 (Aug 1992) ISSN: 0920-8569 [Print] United States
• PMID: 1413543 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• DNA, Viral
• Cysteine Endopeptidases
• adenain

Topics

• Adenoviridae (enzymology, genetics)
• Amino Acid Sequence
• Animals
• Base Sequence
• Cysteine Endopeptidases (chemistry, genetics)
• DNA, Viral (genetics)
• Dogs
• Molecular Sequence Data
• Sequence Homology, Amino Acid