Abstract |
A case of a mammary leiomyosarcoma in a 23-year-old woman is presented. The tumor appeared 16 years after successful treatment of an embryonal rhabdomyosarcoma of the orbit. Rhabdomyosarcomas are the most frequent soft tissue tumors of childhood, the orbit and the paratesticular region being the most common primary site for this tumor. In contrast, leiomyosarcomas other than those evolving from the viscera or the urogenital organs are rare neoplasms at any age. With the improvement of cancer treatment and survival rates, the risk of late effects after successful treatment for malignant tumors during childhood is increasing. Growth, development and fertility may be impaired and cosmetically disturbing facial and dental complications are common. Development of novel primary tumors is a known further consequence of successful treatment of brain tumors, retinoblastoma and acute leukemias. This is the case when high dose local radiation therapy and/or chemotherapy, especially alkylating agents, were used. Development of novel primary tumors is also known after treatment of childhood rhabdomyosarcomas. This report is intended to show that a second primary tumor may occur many years after a first successfully treated malignant neoplasm, and that young people are at risk for development of tumors at sites that are uncommon to this age group.
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Authors | K Buser, H J Altermatt, H Ohnacker, R Fravi, C Oppikofer, A Ridolfi Lüthy, T Cerny, K W Brunner |
Journal | Schweizerische medizinische Wochenschrift
(Schweiz Med Wochenschr)
Vol. 122
Issue 36
Pg. 1335-41
(Sep 05 1992)
ISSN: 0036-7672 [Print] Switzerland |
Vernacular Title | Leiomyosarkom der Mamma 16 Jahre nach erfolgreicher Behandlung eines Rhabdomyosarkoms der Orbita im Kindesalter. |
PMID | 1411391
(Publication Type: Case Reports, English Abstract, Journal Article)
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Chemical References |
- Dactinomycin
- Vincristine
- Cyclophosphamide
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Topics |
- Adult
- Antineoplastic Combined Chemotherapy Protocols
- Breast Neoplasms
(pathology)
- Chemotherapy, Adjuvant
- Child
- Cyclophosphamide
(administration & dosage)
- Dactinomycin
(administration & dosage)
- Female
- Humans
- Leiomyosarcoma
(pathology)
- Neoplasms, Second Primary
- Rhabdomyosarcoma
(pathology, therapy)
- Vincristine
(administration & dosage)
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