Valproate acute administration, EEG epileptic abnormalities, and ammonemia.

Abstract

Acute, oral administration of 14.3 to 37.5 mg/kg magnesium valproate (peak serum concentrations, 65 to 139 micrograms/ml) increases spike-wave frequency at 2, 3, 4, and 5 hours postdrug, in the absence of hyperammonemia or significant correlations with ammonemia fluctuations. This observation suggests a direct role of valproate on neural activity.

• Authors: W G Sannita
• Journal: Neurology (Neurology) Vol. 42 Issue 10 Pg. 2003-5 (Oct 1992) ISSN: 0028-3878 [Print] United States
• PMID: 1407583 (Publication Type: Journal Article)

Chemical References

• Valproic Acid
• Ammonia

Topics

• Adolescent
• Adult
• Ammonia (blood)
• Electroencephalography
• Epilepsy (blood, drug therapy, physiopathology)
• Female
• Humans
• Male
• Valproic Acid (adverse effects, blood, therapeutic use)