[Hemodynamic effects of purine nucleosides in regional ischemia and reperfusion].

Abstract

The rat hearts were subjected to 60-min ischemia by left coronary artery ligation followed by 60-min reperfusion, involving intravenous adenosine inosine or guanosine given in a dose of 1 mg/kg.min-1 in the first 30 minutes of reperfusion. Ischemia and subsequent reperfusion caused a progressive decrease in cardiac output and coronary blood flow. Adenosine was found to enhance coronary blood flow and increase cardiac and stroke outputs. Inosine produced nearly the same, but less pronounced effect. Guanosine increased cardiac output without changing coronary blood flow.

• Authors: N O Selizarova, V V Eliseev
• Journal: Kardiologiia (Kardiologiia) Vol. 32 Issue 5 Pg. 84-7 (May 1992) ISSN: 0022-9040 [Print] Russia (Federation)
• Vernacular Title: Gemodinamicheskie éffecty purinovykh nukleozidov pri regionarnoĭ ishemii i reperfuzii.
• PMID: 1405275 (Publication Type: English Abstract, Journal Article)

Chemical References

• Purine Nucleosides

Topics

• Animals
• Cardiac Output (drug effects)
• Coronary Circulation (drug effects)
• Hemodynamics (drug effects)
• Male
• Myocardial Reperfusion Injury (drug therapy, physiopathology)
• Purine Nucleosides (pharmacology, therapeutic use)
• Rats